Noradrenaline release evoked by a physiological irregular sympathetic discharge pattern is modulated by prejunctional α- and β-adrenoceptors in vivo

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

PRE- AND POSTJUNCTIONAL α-ADRENOCEPTORS IN RABBIT ARTICULAR BLOOD VESSELS

Previous in vitro work on rabbit knee joint vessels showed that vasoconstrictor effects of nerve stimulation and administration of α-adrenoceptor agonists were mediated predominantly by α1-adrenoceptors5,9 The present experiments were performed to assess the nature of α-adrenoceptor subtypes within these blood vessels in vivo. Dose/response relationships for adrenaline and noradrenaline pr...

متن کامل

Hippocampal noradrenaline release in awake, freely moving rats is regulated by alpha-2 adrenoceptors but not by adenosine receptors.

In this study, the ability of the nonselective adenosine receptor antagonist caffeine to influence the concentration of noradrenaline in the central nervous system was investigated, and its effects compared with those of alpha-2 adrenoceptor modulation. The technique of microdialysis in association with microbore high-performance liquid chromatography and electrochemical detection was used to m...

متن کامل

TNF-α production is modulated by Aloe vera gel extract and its fractions in Candida albicans infected macrophages

Background: Aloes have been used as medicinal plants for centuries. The immunomodulatory effect of Aloe vera has previouslybeen shown. Meanwhile, TNF-α, as an inflammatory cytokine, plays an essential role in defense against invading pathogen. Objectives: In the present study, the effects of A. vera extract gel and its fractions were investigated on the TNF-α production bymacrophages against Ca...

متن کامل

Modulation of norepinephrine release from sympathetic neurons of the rabbit aorta by prejunctional prostanoid receptors.

The pharmacological properties and subtypes of prostanoid receptors involved in the prejunctional modulation of [(3)H]norepinephrine release from sympathetic neurons were studied using isolated rabbit aorta. Rings preincubated with [(3)H]norepinephrine were washed with physiological salt solution that contained cocaine plus corticosterone, uptake(1) and uptake(2) inhibitors, respectively, and r...

متن کامل

Presence of prejunctional D2-dopaminoceptors and α2-adrenoceptors on the cholinergic nerve of the common bile duct of guinea pig

On most adrenergic and cholinergic nerve terminals, prejunctional α-adrenoceptors belonging to the α2-subtype have been identified. Activation of these receptors will decrease the release of norepinephrine. It has been reported that several isolated tissue preparations contain prejunctional dopamine receptors, the stimulation of which inhibits neurotransmission. It has remained uncertain whethe...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: British Journal of Pharmacology

سال: 1988

ISSN: 0007-1188

DOI: 10.1111/j.1476-5381.1988.tb11744.x